Update: Even though there might not be any need for my near 60k Solara to be Sea Foamed, I went ahead and did it today.
Poured 1/3 in tank, 1/3 in vacuum...then I poured enough to stall the engine (the remainder poured in the tank - very little).
10 minutes later I started up...the car was a bit difficult to start, but after a bit, it cleared up...
However, it was still smoking for a while, so after a bit, I decided to take it for a ride. Funny thing, while driving on the freeway, a fellow motorist yelled out that I had my car was smoking as if I broke something (smoke was a little blueish). Apparently, the funnel I used to pour the Sea Foam had very little oil residue and it went in the line, but after a minute it went away... Seems I have another Sea Foam date soon.
Edit: This is also something good to do for all those using oiled air filters. The reason performance dry air filters exist is not only due to simpler maintenance, but because oil filters can over time "grease up" the insides of air intake manifold and parts.
Results: The car has a lot better throttle response. There was a lot of traffic, so that was the only thing noticeable.
Thoughts: Even though my car has nearly 60k miles, it never saw an injector cleaner after 20k miles. Also, since I used 93 octane fuel prior to getting a bit more intelligent on the subject, I suspect there could be a little buildup due to both issues. In the end, I'm happy.
Additional Material: This club lexus post has pics on how piston looks after treatment:
http://us.lexusownersclub.com/forums/index.php?showtopic=25167